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Tongkat ali and eurycomanone

The scientific consensus is that most of the therapeutic effects of tongkat ali extract ought to be credited to the chemical component eurycomanone. [1] [2]

Eurycomanone is one of dozens of chemical components found in tongkat ali root. Most of these chemical components are similar to each other and classified as quassinoids. [3] [4]

In Malaysia, where there is very little remaining tongkat ali in forests, it has been tried in a year-long university research program to grow tongkat ali under ideal lab conditions as tissue culture plantlets, with special interests in the yield of eurycomanone.

A slight increase was noted, as summarized in the study abstract:

“… the content of eurycomanone was found to be higher in dried roots of tissue culture plantlets (120.76 ppm/mg) compared with matured root of E. longifolia (101.26 ppm/mg).”

For those not familiar with chemistry lab measurements:

ppm = parts per million

It’s a measurement like percent, as which it can easily be written:

101 ppm = 0.01 percent

100 000 – 10.1 ppm

10 000 – 1.01 ppm

1000 – 0.101 ppm

100 – 0.0101 ppm

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1 Muchsin Darise, Hiroshi Kohda, Kenji Mizutani, Osamu Tanaka Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia, Science Direct, Phytochemistry Volume 21, Issue 8, 1982, Pages 2091-2093

2 Pooi-Fong Wonga, Wei-Fun Cheongb, Meng-Hooi Shub, Chin-Hoe Tehc, Kit-Lam Chanc, Sazaly AbuBakar Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28, Science Direct, Phytochemistry Volume 19, Issue 2, 15 January 2012, Pages 138144

3 Fiaschetti G1, Grotzer MA, Shalaby T, Castelletti D, Arcaro A. Quassinoids: From traditional drugs to new cancer therapeutics., Pub Med, 2011;18(3):316-28

4 Suratwadee Jiwajindaa, Vilai Santisopasrib, Akira Murakamic, Masanori Kawanakad, Hiromu Kawanakad, Monique Gasquete, Riad Eilase, Guy Balansarde, Hajime Ohigashif In vitro anti-tumor promoting and anti-parasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia, Science Direct, Journal of Ethnopharmacology Volume 82, Issue 1, 1 September 2002, Pages 5558